Clue is on a mission to help you understand your body, periods, ovulation, and so much more. Start tracking today. For women and people with vaginas , orgasms most commonly come from the clitoris, located above the vaginal opening and urethra 1,2,3. Erogenous zones are areas of the body that elicit a sexual response when stimulated. The clitoris is one of the most sensitive erogenous zones due to its high concentration of nerve endings 4,5.